Terminal phalageal osteosclerosis.

Osteosclerosis in myeloma.

In multiple myeloma the typical bone lesions are usually purely osteolytic and the presence of any osteosclerosis suggests that the diagnosis should be reconsidered. There have now been reports of forty-nine patients with myeloma with osteosclerotic deposits in whom radiotherapy could not be implicated as a cause (Kr , Wiedermann, Vykydal and Soyka 1967; Evison and Evans 1967; Osuntokun, Akinku...

Osteosclerosis Secondary to Metastatic Oligodendroglioma

This paper reviews a case of metastatic 1p/19q codeleted oligodendrioglioma causing diffuse osteosclerosis and pain. Primary central nervous system (CNS) tumors rarely metastasize outside the CNS, and metastatic oligodendroglioma is rarer still. The patient in this study had relief of pain after being treated with temozolomide. We discuss this rare presentation and potential treatment options, ...

Acute Myelocythæmia Associated with Osteosclerosis

Diffuse osteosclerosis in hairy cell leukemia.

We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatmen...

Pathogenesis of osteosclerosis in autosomal dominant osteopetrosis.

OBJECTIVE The purpose of this study was to determine if the generalized osteosclerosis seen on skeletal radiographs of patients with osteopetrosis is associated with an increase in bone density. SUBJECTS AND METHODS Five children (three girls, two boys, 6-12 years old) with autosomal dominant osteopetrosis who had sustained a fracture with minimal trauma had the density and area of cortical b...